Haṭha Yoga Pradīpikā Chapter Three verse 14

महाक्लेशादयो दोषाः क्षीयन्ते मरणादयः ।
महामुद्रां च तेनैव वदन्ति विबुधोत्तमाः ॥१४॥

mahākleśādayo doṣāḥ kṣīyante maraṇādayaḥ |
mahāmudrāṁ ca tenaiva vadanti vibudhottamāḥ ||

“It dissolves defects like the Mahā Kleśa such as the fear of Death.
For this reason the wise call it the Mahāmudrā”

mahā - greatkleśa - afflictionsdoṣa - affection, defect, fault, biological humoursmudrā - sealmahāmudrā - great seal